Urea crosslinker – C3-arm, NHS ester (DSPU)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL007_0050 | 0.05 g | Enquire | in stock | |
| PCL007_0100 | 0.1 g | Enquire | in stock |
- IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-(carbonylbis(azanediyl))dipropionate
- Synonyms: C3-Urea-NHS-crosslinker, Urea-crosslinker C3-succinimide, DSPU
- CAS: 2185840-20-2
- Smiles: O=C(ON1C(CCC1=O)=O)CCNC(NCCC(ON2C(CCC2=O)=O)=O)=O
- Chemical formula: C15H18N4O9
- Molecular weight: 398.32
- Purity: 95%+
Ureido-3,3´-dipropionic acid bis(hydroxysuccinimide) ester is the medium length version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows to perform unambiguous distinguishing of crosslinks in tandem CID-MS experiments.
The urea-based MS-cleavable crosslinkers are based on the concept pioneered by Prof. Dr. Andrea Sinz of the Halle University.