Urea crosslinker – C2-arm, NHS ester (DSAU)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL006_0050 | 0.05 g | Enquire | in stock | |
| PCL006_0100 | 0.1 g | Enquire | in stock |
- IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(carbonylbis(azanediyl))diacetate
- Synonyms: C2-Urea-NHS-crosslinker, Urea-crosslinker C2-succinimide, DSAU
- CAS: 211029-82-2
- Smiles: O=C(ON1C(CCC1=O)=O)CNC(NCC(ON2C(CCC2=O)=O)=O)=O
- Chemical formula: C13H14N4O9
- Molecular weight: 370.27
- Purity: 95%+
Ureido-2,2´-diacetic acid bis(hydroxysuccinimide) ester is the shortest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows to perform unambiguous distinguishing of crosslinks in tandem CID-MS experiments.
The urea-based MS-cleavable crosslinkers are based on the concept pioneered by Prof. Dr. Andrea Sinz of the Halle University.