Sodium azidodifluoroacetate 0.25 M solution in water
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| FAZ013_1 | 1 ml | 195,00 € | in stock | |
| FAZ013_2.5 | 2.5 ml | 350,00 € | in stock | |
| FAZ013_5 | 5 ml | 500,00 € | in stock |
- IUPAC Name: Sodium 2-azido-2,2-difluoroacetate
- Synonyms:
- CAS: N/A
- Smiles: FC(C(O[Na])=O)(F)N=[N+]=[N-]
- Chemical formula: C2F2N3NaO2
- Molecular weight: 159.03
- Purity: 95%+
Sodium azidodifluoroacetate introduces a charged fluorinated motif to drug candidates by click chemistry.
Owing to the electron withdrawing effect of fluorine substituents, azidodifluoroacetic acid and triazoles derived from it are expected to have significantly lower pKa values comparable to trifluoroacetic acid.
Furthermore, when attached to an alkynylated biolomolecule (protein, peptide, nucleic acid, glycan, etc.) or advanced material, it can act as a 19F NMR sensor of its surroundings.
Despite the relatively low 19F NMR integration intensity, it can be beneficial in cases where organic cosolvents should be avoided or aqueous solubility of the resulting conjugate must not be compromised or should be improved. .