Publications
Publication describing the development a novel technology for fluoroalkylation of amino acid residues in peptides and proteins.
Rahimidashaghoul K., Klimánková I., Hubálek M., Korecký M., Chvojka M., Pokorný D., Matoušek V., Fojtík L., Kavan D., Kukačka Z., Novák P., Beier P.:
Reductant‐Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins.
Publication describing the synthesis of novel water-soluble hypervalent iodine reagent for thiol conjugation
Klimánková I., Hubálek M., Matoušek V., Beier P.:
Synthesis of water-soluble hypervalent iodine reagents for fluoroalkylation of biological thiols.
Publication describing the access to difluoromethyl azide and its application in copper-catalyzed azide-alkyne cycloaddition (CuAAC)
Voltrová S., Putovny I., Matoušek V., Klepetářová B., Beier P.:
Reintroducing Azidodifluoromethane: Synthesis, Stability and [3+2] Cycloadditions.
Publication describing the synthesis of perfluoroalkylazides from nucleophilic perfluoroalkyl sources and their application in copper-catalyzed azide-alkyne cycloaddition (CuAAC)
Blastik Z.E., Voltrová S., Matoušek V., Jurásek B., Manley D., Klepetářová B., Beier P.:
Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition.
Publication describing the synthesis of tetrafluoroalkyl azides of the formula RCF2CF2N3 and their application in copper-catalyzed azide-alkyne cycloaddition (CuAAC)
Voltrová S., Muselli M., Filgas J., Matoušek V., Klepetářová B., Beier P.:
Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application.
Publication describing the development an amine platform Togni reagent, its late-stage functionalisation and the application of the complex Togni reagents to chemoselective thiol bioconjugation
Václavík J., Zschoche R., Klimánková I., Matoušek V., Beier P., Hilvert D., Togni A.:
Irreversible Cysteine-Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents.
Publication describing the magnesiation of fluoroalkylbromides of the formula RCF2CF2Br and their application in synthesis of tetrafluoroethylated small molecules
Budinská A., Václavík J., Matoušek V., Beier P.:
Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents.
Seminal publication describing the discovery and development of Togni-CF2CF2R reagents
Matoušek V., Václavík J., Hájek P., Charpentier J., Blastik Z.E., Pietrasiak E., Budinská A., Togni A., Beier P.:
Expanding the Scope of Hypervalent Iodine Reagents for Perfluoroalkylation: From Trifluoromethyl to Functionalized Perfluoroethyl.