GMBS crosslinker
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL031_0050 | 50 mg | Enquire | in stock | |
| PCL031_0100 | 100 mg | Enquire | in stock |
- IUPAC Name: 4-Maleimidobutyric acid N-hydroxysuccinimide ester
- Synonyms: 4-maleimidobutyric acid N-hydroxysuccinimide ester, N-succinimidyl 4-maleimidobutyrate, 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoate, N-γ-maleimidobutyryl-oxysuccinimide ester, GMBS, N-(γ-maleimidobutyryloxy)succinimide
- CAS: 80307-12-6
- Smiles: O=C(CC1)N(OC(CCCN2C(C=CC2=O)=O)=O)C1=O
- Chemical formula: C12H12N2O6
- Molecular weight: 280.237
- Purity: 95%+
GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).
Features of GMBS:
• Reactive groups: NHS ester and maleimide
• Reactive toward: amino and sulfhydryl groups
• C4-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
• NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-GMBS
• Short aliphatic spacer has low potential for eliciting an immune response