EMCS crosslinker
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL032_0050 | 50 mg | Enquire | in stock | |
| PCL032_0100 | 100 mg | Enquire | in stock |
- IUPAC Name: 6-maleimidohexanoic acid N-hydroxylsuccinimide ester
- Synonyms: 6-maleimidohexanoic acid N-hydroxylsuccinimide ester, N-succinimidyl-6-maleimidylhexanoate, 6-maleimidohexanoic acid N-hydroxysuccinimide ester, N-succinimidyl 6-maleimidohexanoate, 6-(maleimido)hexanoic acid succinimidyl ester, 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate,2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxopyrrol-1-yl)hexanoate,2,5-dioxypyrrolidin-1-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate, Mc-OSu, EMCS
- CAS: 55750-63-5
- Smiles: O=C(CC1)N(OC(CCCCCN2C(C=CC2=O)=O)=O)C1=O
- Chemical formula: C14H16N2O6
- Molecular weight: 308.291
- Purity: 95%+
EMCS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).
Features of EMCS:
• Reactive groups: NHS ester and maleimide
• Reactive towards: amino and sulfhydryl groups
• C6-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
• NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-EMCS
• Increased sphere of coupling vs. GMBS
• Short aliphatic spacer has low potential for eliciting an immune response