DSSO crosslinker
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL039_0050 | 50 mg | 50,00 € | in stock | |
| PCL039_0100 | 100 mg | 90,00 € | in stock |
- IUPAC Name: bis(2,5-Dioxopyrrolidin-1-yl) 3,3'-sulfinyldipropionate
- Synonyms: DSSO
- CAS: 1351828-03-9
- Smiles: O=C(ON1C(CCC1=O)=O)CCS(CCC(ON2C(CCC2=O)=O)=O)=O
- Chemical formula: C14H16N2O9S
- Molecular weight: 388,35
- Purity: 95%+
DSSO (disuccinimidyl sulfoxide) crosslinker is a homobifunctional, amine-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). Membrane-permeable DSSO possesses two N-hydroxysuccinimide (NHS) esters for targeting Lys, a 10.1 Å spacer arm, and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. DSSO Crosslinker provides complementary data to thiol-reactive and acidic residue-targeting reagents and will find wide utility in the elucidation of PPIs, study of proteins that function as complexes, quantification of structural dynamics, and the quest for targeting ″undruggable″ protein targets.