Di-(N-succinimidyl) sebacate
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL003_1 | 1 g | 50,00 € | in stock | |
| PCL003_5 | 5 g | 190,00 € | in stock | |
| PCL003_10 | 10 g | 300,00 € | in stock | |
| PCL003_50 | 50 g | 1.350,00 € | in stock |
- IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) decanedioate
- Synonyms: DSSeb, Disuccinimidyl sebacate, Disuccinimidyl decanedioate
- CAS: 23024-29-5
- Smiles: O=C(ON1C(CCC1=O)=O)CCCCCCCCC(ON2C(CCC2=O)=O)=O
- Chemical formula: C18H24N2O8
- Molecular weight: 396.39
- Purity: 98%+
Di-(N-succinimidyl) sebacate is an amine-reactive homobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups and N-termini. It represents the longest of the 3 most used neutral N-crosslinkers.
DSSeb crosslinker (Disuccinimidyl sebacate; Sebacic acid bis[N-hydroxysuccinimide ester]) is a homobifunctional crosslinking reagent which is cell membrane permeable. DSSeb crosslinking takes place via amine-reactive NHS esters at both ends of a 10-atom (14.1 Angstrom) spacer arm. DSSeb must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.