SMCC crosslinker
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL025_0050 | 0,05 g | 18,00 € | in stock | |
| PCL025_0100 | 0,1 g | 25,00 € | in stock | |
| PCL025_0250 | 0,25 g | 40,00 € | in stock | |
| PCL025_1 | 1 g | 90,00 € | in stock |
- IUPAC Name: 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester
- Synonyms: 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid succinimidyl ester, N-succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Maleimidylmethyl-4-trans-cyclohexylcarboxysuccinate, SMCC
- CAS: 71875-81-5
- Smiles: O=C(CC1)N(OC([C@@H]2CC[C@@H](CN3C(C=CC3=O)=O)CC2)=O)C1=O
- Chemical formula: C16H18N2O6
- Molecular weight: 334.329
- Purity: 97%+
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent containing amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.